The earthquake in Pakistan brings up the point that there are lots of earthquakes in Central Asia. Most are not well known, but several have caused major destruction in capital cities, or ancient cities on the Silk Road. Here are four of the biggest recent earthquakes in Kyrgyzstan. I'll do some other Central Asian countries later.
A 7.3-magnitude earthquake hit the Fergana Valley in Kyrgyzstan in 1992 and a similar one again in 1997.
A strong earthquake in 1885 near Bishkek (probably around 6.9)
A 8.2 in Kemin, along the road from Bishkek to Issyk-Kul.
A 1946 7.6 Chatkal earthquake near Karakol.
These are some big earthquakes in the last 120 years in a relatively small area. Most haven't caused too much loss of life because of low population usually, but if an earthquake hit near Bishkek again with its many people and multi-story concrete buildings, I wouldn't have much hope for the city.